Syntocinon versus ergometrine in the active management of the third stage of labour in Omdurman Maternity Hospital July - October 1996 .


Research type: Research Paper

Authors: El Mahadi, El Waleed Mohamme Ahmed .

Abstract: Active management of the third stage of labour is a routine policy widely practiced. The pharmacological component of this policy is quit variable workdwide. Ergometrine is the most commonly used oxytocic in Sudan, it has side effects which are known to be associated with it's use. In this double blind controlled clinical trial, conducted in Omdurman Maternity Hospital in the period July - October 1995, we planned to assess the possible difference in strength of ergometrine 0.5mg and syntocinon 10 units. Total of 247 were recriuted, those who had multiple pregnancy, high blood pressure, and other factors predisposing for postpartum, haemmorhage were excluded, and using table of a computer generated random number, 113 cases were allovated to receive syntocinon and 134 ergometrine, and either drug being given with delivery of the anterior shoulder. The parameters observed were postpartum blood loss, nausea, vomiting, headache, and any change in blood pressure, the length of the third stage was also recorded. The mean blood loss was almost similar in the groups allocated to ergometrine or syntocinon, being 233 ml and 226 ml (P equal 0.686), and the third stage showed no significant difference (P equal 0.468) being 4.05 and 3.85 minutes respectively. The incidence of nausea was found mainly in the ergometrine group 36 patients (26.9 percent), and only 5 cases (4.4 precent) in the syntocinon group perhaps makes oxytocics not the only factor responsible for this symptom. Vomiting and headache were only reported in the ergometrine group. The rise in blood pressure again was quite evident in the ergometrine group. From the study it is clear that both oxytocics have got similar power in limiting postpartum blood loss, and decreasing the risk of postpartum haemorrhage. The association of ergometrine with the above mentioned side effects, makes syntocinon 10 units better choice as oxytocic for routine use .